IREx modified the Institutional Profile (IP) by replacing most file upload fields with text boxes and included new fields in Sections 1, 2, and 4. On May 20, 2025, all IPs were set to ‘Incomplete’, and HRPP Liaisons are required to complete the new text fields replacing the file uploads; answer the new questions in Sections 1 & 2; and review/update Section 4 if currently or plan to use IREx as the single IRB. Relying HRPPs will be required to update before they can cede reliance. The pop up Relying HRPPs see when their IP is incomplete is updated to include information about these changes. The IP PDFs on the IREx website is updated once new IP questions are completed.