A freely available, web-based portal supporting single IRB review documentation and coordination for multi-center clinical trials.
Agreement Checker
The Agreement Checker can be useful in gauging site readiness and preparing reliance instruction for sites. Check if participating sites on your study are ready to rely on the sIRB!
sIRBs in IREx
51 institutions are using IREx as their single IRB portal to document reliance, capture local considerations, and share sIRB approval with relying sites. Join them!
Newest Features
Automating Local Considerations
IREx has simplified the local considerations documentation and review process through automating local considerations. IREx matches Reviewing IRB-informed study elements (i.e., study is recruiting pregnant persons, study includes drugs/devices, etc.) with information from the Institutional Profile (IP) to populate the study-specific HRP Survey that Relying Sites review and submit. This streamlined, automated process minimizes reporting of duplicative or contradictory information from Relying HRPPs and simplifies the review for the Reviewing IRB. For more information, view the announcement here, and a feature overview here.
Our Metrics
As of September 30, 2025 ...
- 92% of sites in IREx have completed their Institutional Profile
- 89% of IREx sites used IREx to rely on a sIRB
- 90% of sites have made it through the sIRB process and received initial approval
- 51 single IRBs are using IREx for over 800 studies
- 13 median days from sIRB submission to sIRB approval for relying sites (not including local review time)
