A freely available, web-based portal supporting single IRB review documentation and coordination for multi-center clinical trials.
What is IREx?
Supporting Single IRB Documentation and Coordination
Basic Reliance Documentation
Track cede decisions and agreements completion
Advance Reliance Documentation
Capture site-specific local considerations and sIRB approvals for relying sites
Single IRB Coordination
Coordinate site readiness for sIRB review, facilitate submissions, and share approvals
For Single IRB Collaborators
sIRBs in IREx
49 institutions are using IREx as their single IRB portal to document reliance, capture local considerations, and share sIRB approval with relying sites. Join them!
Newest Features
Support for Single IRB studies using Exception From Informed Consent (EFIC)
IREx now supports studies using the EFIC process. Using IREx to implement your EFIC workflow helps lead study teams track sites in various stages of the EFIC process; standardizes and centralizes EFIC documentation for the sIRB and relying HRPPs; and provides sites with clear EFIC processes and approval statuses. Watch this video and read this announcement to learn more.
Our Metrics
As of March 31, 2025 ...
- 92% of sites in IREx have completed their Institutional Profile
- 88%of IREx sites used IREx to rely on a sIRB
- 90% of sites have made it through the sIRB process and received initial approval
- 49 single IRBs are using IREx for over 700 studies
- 13 median days from sIRB submission to sIRB approval for relying sites (not including local review time)
