A freely available, web-based portal supporting single IRB review documentation and coordination for multi-center clinical trials.
Agreement Checker
The Agreement Checker can be useful in gauging site readiness and preparing reliance instruction for sites. Check if participating sites on your study are ready to rely on the sIRB!
sIRBs in IREx
51 institutions are using IREx as their single IRB portal to document reliance, capture local considerations, and share sIRB approval with relying sites. Join them!
Newest Features
Enhanced Indemnification Tracking
- SMART Indemnification Addendum status automatically tracked in IREx
- Ability to utilize multiple indemnification agreement on a single study
Automating Local Considerations
- Study elements identified by the Reviewing IRB (i.e., study is recruiting pregnant persons, study includes drugs/devices, etc.) matched with relevant information from the Institutional Profile (IP)
- Relying Site’s study-specific HRP Survey is auto-populated with that relevant information from IP
- Relying Site reviews and submits
- Ability to add custom, study-specific questions to the HRP and PI local context surveys (e.g., What is standard of care at your site?)
- Minimizes duplicative local considerations information submitted by Relying HRPP
- Simplifies review for Reviewing IRB
Our Metrics
As of June 30, 2026 ...
- 97% of sites in IREx have completed their Institutional Profile
- 90% of IREx sites used IREx to rely on a sIRB
- 92% of sites have made it through the sIRB process and received initial approval
- 51 single IRBs are using IREx for over 800 studies
- 13 median days from sIRB submission to sIRB approval for relying sites (not including local review time)
