What is IREx?


A freely available, web-based portal supporting single IRB review documentation and coordination for multi-center clinical trials.

What is IREx?

Supporting Single IRB Documentation and Coordination

Basic Reliance Documentation

Track cede decisions and agreements completion

Advance Reliance Documentation

Capture site-specific local considerations and sIRB approvals for relying sites

Single IRB Coordination

Coordinate site readiness for sIRB review, facilitate submissions, and share approvals

For Single IRB Collaborators

Single IRBs

capture information from site HRPPs & study teams

Relying Institutions

document reliance & local considerations

Local Study Teams

communicate with the sIRB & retrieve sIRB approvals

Lead Study Teams

track site progress towards sIRB review & approval

sIRBs in IREx

44 institutions are using IREx as their single IRB portal to document reliance, capture local considerations, and share sIRB approval with relying sites. Join them!

Newest Features

Disseminate New Instructions & Study Team Access to Lead Site Approval

sIRBs can now confirm new Agreement and Single IRB Instructions in the IREx Setup to send to participting sites. Lead Study Teams can disseminate the instructions and give study teams immediate access to IREx to access the lead site sIRB approval by a press of a button in IREx. 

Our Metrics

As of March 31, 2024...

  • 90% of sites in IREx have completed their Institutional Profile
  • 93% of IREx sites have indicated reliance
  • 88% of sites have ceded review and have approval posted to IREx
  • 32 out of 44 single IRBs using IREx for one or more studies
  • 11 median days from initial sIRB submission to sIRB approval for relying sites (not including local review time)

What Our Users Say

Read what our users are saying about IREx!