Frequently Asked Questions

  • Can IREx only be used with Trial Innovation Network (TIN) studies? 

    No. IREx can be used by any institution serving as the Reviewing IRB.The TIN central IRBs utilize IREx to support single IRB review of all TIN studies. Use of IREx is required for all TIN studies, as is use of the SMART IRB Agreement. Additionally, IREx can be used for non-TIN studies using the SMART IRB Agreement or another reliance agreement.

  • Can IREx only be used with the SMART IRB Agreement?

    No. While IREx recommends all institutions use the SMART IRB Agreement to support all reliance arrangements, IREx can be used with other reliance agreements and authorization agreements.

  • What institutions can become IREx members?

    US-based institutions with a Federalwide Assurance (FWA). Check to see if your Institution has an FWA here.

  • How can my institution join IREx? 

    The institution and IRB, if applicable, review and sign the IRB Reliance Exchange Portal Agreement, and IREx Liaisons from your Institution’s Human Research Protection Program or IRB are identified. After signing the portal agreement:

    • Scan the signed and completed agreement to admin@IRBexchange.org.
    • After your Institution joins IREx, access is provided to one or two IREx Liaisons (your HRP Administrator or individuals from your HRPP or IRB).
    • Note: Investigators and study teams are given access to IREx on a study-by-study basis.

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